Recombinant LAMP3 protein (His tag)

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Introducing the recombinant human Lysosome-associated membrane glycoprotein 3 (LAMP-3/CD208) fragment (residues 213-381), a highly stable and soluble protein unit ideal for investigating lysosomal function, autophagy, and immune cell biology. This fragment is optimized for structural and biochemical studies, offering researchers a reliable tool to explore key cellular processes.

Lysosome-associated membrane glycoprotein 3 (LAMP-3), also known as DC-LAMP or CD208, is a human lysosomal membrane protein that plays a critical role in the unfolded protein response, promoting protein degradation and cell survival during proteasomal dysfunction. It modulates autophagy by facilitating lysosome-autophagosome fusion and contributes to hepatocellular lipogenesis via the PI3K/Akt pathway. In dendritic cells, LAMP-3 supports adaptive immunity and is localized to lysosomal membranes, cytoplasmic vesicles, early endosomes, and the cell surface. Additionally, it is implicated in viral infections, aiding influenza A virus replication, mumps virus fusion protein processing, and Salmonella typhimurium intracellular proliferation. The fragment (residues 213-381) represents a computationally selected stable region, enabling focused analysis of these multifaceted functions.