Recombinant KLRG1 protein (His tag)

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Recombinant KLRG1 (C-type lectin domain fragment) is a high-purity protein fragment corresponding to amino acids 60-195 of human Killer cell lectin-like receptor subfamily G member 1. This fragment encompasses the complete C-type lectin domain, making it an ideal tool for studying inhibitory signaling mechanisms in natural killer (NK) cells and T-cells, particularly through cadherin binding interactions.

KLRG1 (Killer cell lectin-like receptor subfamily G member 1) is an inhibitory receptor expressed on natural killer (NK) cells and T-cells that plays a crucial role in immune regulation. The protein functions by binding to conserved sites on classical cadherins (including E-cadherin/CDH1, N-cadherin/CDH2, and R-cadherin/CDH4), enabling it to monitor cadherin expression on target cells and mediate 'missing self' recognition. This inhibitory signaling helps regulate immune cell functions when cadherins are present on target cells. KLRG1 is localized to the cell membrane as a single-pass type II membrane protein, positioning it optimally for cell surface interactions and signal transduction.