Recombinant KLD8B protein (His tag)

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Recombinant Human Kelch domain-containing protein 8B (KLHDC8B) fragment (amino acids 1-354) - a high-quality, soluble protein preparation ideal for studying cytokinesis, mitotic integrity, and chromosomal stability mechanisms.

Kelch domain-containing protein 8B is a crucial cellular regulator involved in multiple aspects of cell division. The full-length protein plays essential roles in pinching off separated nuclei at the cleavage furrow during cytokinesis and is required for maintaining mitotic integrity and chromosomal stability. KLHDC8B protects cells against mitotic errors, centrosomal amplification, micronucleus formation, and aneuploidy. It demonstrates a key function in midbody operations involving abscission of daughter cells during cytokinesis and ensures appropriate chromosomal and nuclear segregation into daughter cells. The protein localizes primarily to the cytoplasm and specifically concentrates in the midbody of the cytoplasmic bridge linking daughter cells as they separate during cytokinesis, highlighting its critical role in the final stages of cell division.