KIR2DL3 antibody

KIR2DL3 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

KIR2DL3 Rabbit Polyclonal antibody. Positive WB detected in human liver tissue. Observed molecular weight by Western-blot: 58 kDa

ELISA, WB

human; other species not tested.

KIR2DL3 antibody; CD158B2 antibody; NKAT2 antibody; MHC class I NK cell receptor antibody; KIR K7c antibody

Rabbit IgG

This antibody was obtained by immunization of KIR2DL3 recombinant protein (Accession Number: NM_015868). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Killer cell immunoglobulin-like receptors (KIRs) are a diverse family of inhibitory and activating receptors expressed on NK cells and a subset of T cells (PMID: 11861603). These polymorphic receptors interact with specific motifs on HLA class I molecules, modulate NK cytolytic activity and are encoded by genes located on chromosome 19q13.4 (PMID: 17069649). KIR2DL3, also known as CD158B2 or NKAT2, is an inhibitory receptor that is specific for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7) (PMID: 10196125). It is a 341-amino acid transmembrane glycoprotein consisting of an extracellular region containing two C2-type Ig-like domains, a 19-amino acid hydrophobic transmembrane region, and a long cytoplasmic tail with two immunoreceptor tyrosine-based inhibitory motifs (ITIMs). KIR2DL3 inhibits the cytolytic activity of NK cells thus preventing cell lysis (PMID: 7724594).