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Product Name
Recombinant KIF15 protein (His tag)
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Description
Recombinant Human KIF15 (Kinesin-like protein KIF15) fragment (amino acids 1-447) is a high-purity protein designed for studying the kinesin motor domain's role in mitotic spindle assembly and microtubule dynamics. This fragment provides an essential tool for investigating the molecular mechanisms of cell division and motor protein function.
KIF15 is a plus-end directed kinesin-like motor enzyme crucial for mitotic spindle assembly during cell division. The full-length protein localizes to the cytoplasm during interphase and transitions to the mitotic spindle during mitosis, where it colocalizes with TPX2. It also associates with the central spindle during anaphase and appears at invaginating cell membrane sites corresponding to the contractile actomyosin ring. Additionally, KIF15 colocalizes with actin in interphase and with microtubules in neuronal dendrites and growth cones, highlighting its diverse roles in cytoskeletal organization and cellular transport processes.
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Protein name
Kinesin-like protein KIF15
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Uniprot ID
Q9NS87
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Gene Name
KIF15; KLP2; KNSL7
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 1-447 aa (Q9NS87) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 50.98 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 51 kDa band.
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Purity
>86%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"