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Product Name
KIDINS220 antibody
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Description
KIDINS220 Rabbit Polyclonal antibody. Positive WB detected in HeLa cells, HEK-293 cells, human brain tissue, Raji cells. Observed molecular weight by Western-blot: 186-197 kDa
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Tested applications
ELISA, WB
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
ARMS antibody; KIAA1250 antibody; KIDINS220 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of KIDINS220 recombinant protein (Accession Number: NM_001348736). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
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Validations
HeLa cells were subjected to SDS PAGE followed by western blot with Catalog No:111998(KIDINS220 antibody) at dilution of 1:1000
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Background
Kidins220 (Kinase D-interacting substrate 220 kD) is a crucial mediator of signal transduction in neural tissues. Also it named ARMS(Ankyrin Repeat-Rich Membrane Spanning) due to the presence of ankyrin repeats and transmembrane domains together with other binding motifs. It is a multidomain transmembrane protein that not only transduces signaling mediated by the receptor tyrosine kinase (RTK), but also regulates the stability of cytoskeletal network through a number of cytoskeleton-associated proteins, including Septin5, MAPs , and stathmin family members.
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References
- Fiala GJ, Janowska I, Prutek F. Kidins220/ARMS binds to the B cell antigen receptor and regulates B cell development and activation. The Journal of experimental medicine. 212(10):1693-708. 2015.
- Steinberg F, Gallon M, Winfield M. A global analysis of SNX27-retromer assembly and cargo specificity reveals a function in glucose and metal ion transport. Nature cell biology. 15(5):461-71. 2013.
- Gallon M, Clairfeuille T, Steinberg F. A unique PDZ domain and arrestin-like fold interaction reveals mechanistic details of endocytic recycling by SNX27-retromer. Proceedings of the National Academy of Sciences of the United States of America. 111(35):E3604-13. 2014.
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