Recombinant KCNH2 protein (His tag)

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Recombinant Human KCNH2 (hERG1) PAS Domain Fragment (residues 1-132) – a high-purity, functionally relevant protein fragment ideal for studying the structural and regulatory roles of the PAS domain in voltage-gated inwardly rectifying potassium channel activity. This product is designed for researchers investigating ion channel function, modulation, and associated disease mechanisms.

The full-length KCNH2 protein, also known as hERG1, is a pore-forming subunit of voltage-gated inwardly rectifying potassium channels. It plays a critical role in cardiac electrophysiology by mediating rapid inactivation during depolarization and slow deactivation during repolarization, contributing to the characteristic inward rectification. The channel's activity is modulated by cAMP and heteromultimerization with regulatory subunits such as KCNE1 and KCNE2. KCNH2 is localized to the cell membrane as a multi-pass membrane protein and is essential for normal cardiac rhythm, with mutations linked to long QT syndrome. The provided fragment encompasses the PAS domain (residues 41-70), which is involved in channel gating and regulation, making it a valuable tool for domain-specific functional studies.