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Product Name
Recombinant KAISO protein (His tag)
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Description
Recombinant Human Transcriptional Regulator Kaiso (ZBTB33) Fragment (1-116) is a high-purity protein designed to encompass the BTB domain, enabling targeted investigation into its role in transcriptional regulation, chromatin remodeling, and interaction with corepressor complexes.
Transcriptional regulator Kaiso, encoded by the ZBTB33 gene, functions as a bimodal DNA-binding protein that recognizes both methylated CpG dinucleotides (5'-CGCG-3') and non-methylated consensus sequences (5'-CTGCNA-3'). It recruits the N-CoR repressor complex to promote histone deacetylation and repressive chromatin formation, contributing to the repression of Wnt signaling targets and MMP7 expression. Kaiso can also activate transcription via CTNND2 recruitment. Localized primarily in the nucleus, it exhibits cytoplasmic presence in high-density cell cultures, reflecting its dynamic regulatory roles in gene expression and cellular signaling pathways.
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Protein name
Transcriptional regulator Kaiso
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Uniprot ID
Q86T24
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Gene Name
ZBTB33; KAISO; ZNF348
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 1-116 aa (Q86T24) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 14.76 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 15 kDa band.
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Purity
>90%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"