Recombinant JAML protein (His tag)

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Recombinant Human JAML (Junctional adhesion molecule-like) Fragment (aa 20-275) is a high-purity protein designed for studying leukocyte migration and activation. This fragment encompasses the complete Ig-like V-type domains, making it an ideal tool for investigating CXADR-mediated signaling in immune and epithelial cell interactions.

JAML is a transmembrane protein expressed on leukocyte plasma membranes that regulates cell migration and activation through interaction with CXADR on adjacent epithelial and endothelial cells. This interaction is critical for activating gamma-delta T-cells, which reside in epithelia and contribute to tissue homeostasis and repair. Upon binding to epithelial CXADR, JAML initiates downstream signaling through PI3-kinase and MAP kinases, leading to T-cell proliferation and production of cytokines and growth factors that promote tissue repair. Additionally, JAML facilitates leukocyte transmigration across epithelial and endothelial barriers through adhesive interactions with CXADR. The protein localizes to the cell membrane as a single-pass type I membrane protein and is enriched at cell-cell contact sites, highlighting its role in intercellular communication.