Recombinant JAM3 protein (His tag)

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Recombinant Human Junctional Adhesion Molecule C (JAM-C) Fragment (residues 32-241) is a high-purity protein designed for studying cell adhesion and migration mechanisms. This fragment includes the complete Ig-like V-type and C2-type domains, making it an ideal tool for investigating JAM-C's interactions with JAM2 and ITGAM in hematopoietic, endothelial, and immune cell processes.

JAM-C, encoded by the JAM3 gene, is a key junctional adhesion protein that mediates heterotypic cell-cell interactions via its receptor JAM2. It plays critical roles in hematopoietic stem cell retention in bone marrow, leukocyte extravasation through endothelial transmigration, spermatogenesis via Sertoli-germ cell anchorage, and angiogenesis. The full-length protein is a single-pass type I membrane protein localized to cell membranes, desmosomes, and tight junctions, with a cleaved soluble form (sJAM-C) that promotes endothelial chemotaxis. This recombinant fragment (32-241) retains the functional Ig-like domains essential for ligand binding and is validated for research on cell adhesion, migration, and signaling pathways.