Recombinant IWS1 protein (His tag)

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Recombinant Human IWS1 Protein Fragment (aa 527-706) is a high-purity, functional protein fragment derived from the IWS1 homolog, designed to encompass the TFIIS N-terminal domain. This product serves as an essential tool for researchers studying transcription elongation, RNA polymerase II complex assembly, and domain-specific interactions in gene expression regulation.

The full-length IWS1 protein is a critical transcription factor in Homo sapiens that defines the composition of the RNA polymerase II (RNAPII) elongation complex and modulates mature mRNA production. It acts as an assembly factor by binding to SUPT6H on the RPB1 CTD, recruiting mRNA export factors (e.g., ALYREF/THOC4, EXOSC10) and histone-modifying enzymes (e.g., SETD2) to facilitate mRNA splicing, efficient export, and elongation-coupled H3K36 methylation, a hallmark of active transcription. IWS1 is localized exclusively in the nucleus, underscoring its central role in transcriptional regulation and chromatin dynamics.