-
Product Name
Recombinant IVD protein (His tag)
- Documents
-
Description
Recombinant Human Isovaleryl-CoA Dehydrogenase, Mitochondrial (IVD) Fragment (35-426) is a high-purity, stable protein fragment designed for structural and biochemical studies. This 392-amino acid fragment retains key functional regions, making it an ideal tool for investigating leucine catabolism and short-chain acyl-CoA oxidation in mitochondrial pathways.
Isovaleryl-CoA dehydrogenase (IVD) is a mitochondrial matrix enzyme that catalyzes the conversion of isovaleryl-CoA/3-methylbutanoyl-CoA to 3-methylbut-2-enoyl-CoA as a critical step in the leucine catabolic pathway. Additionally, it demonstrates activity toward other saturated short-chain acyl-CoA thioesters, including pentanoyl-CoA, hexenoyl-CoA, and butenoyl-CoA. As a mitochondrial enzyme, IVD localizes to the mitochondrial matrix, where it plays an essential role in energy metabolism and amino acid degradation, with implications for understanding metabolic disorders related to leucine metabolism.
-
Protein name
Isovaleryl-CoA dehydrogenase, mitochondrial
-
Uniprot ID
P26440
-
Gene Name
IVD
-
Source/Expression Host
E. coli
-
Expression Plasmid/cDNA
DNA encoding 35-426 aa (P26440) were fused with 6His tag.
-
Protein Species
Human
-
Molecular weight
Predictes a molecular mass of 44.50 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 45 kDa band.
-
Purity
>85%, by SDS-PAGE with Coomassie Brilliant Blue staining.
-
Activity
Not tested.
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"