ITPR1 Polyclonal Antibody

Cat.#: 161891

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Product Information

  • Product Name
    ITPR1 Polyclonal Antibody
  • Documents
  • Description
    Polyclonal antibody to ITPR1
  • Tested applications
    WB, IF
  • Species reactivity
    Human, Mouse, Rat
  • Alternative names
    ITPR1 antibody; ACV antibody; CLA4 antibody; INSP3R1 antibody; IP3R antibody; IP3R1 antibody; PPP1R94 antibody; SCA15 antibody; SCA16 antibody; SCA29 antibody; inositol 1,4,5-trisphosphate receptor type 1 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 1100-1250 of human ITPR1 (NP_001161744.1).
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • Storage instructions
    Store at -20℃. Avoid freeze / thaw cycles.
  • Applications
    WB 1:500 - 1:2000
    IF 1:50 - 1:200
  • Validations

    Western blot - ITPR1 Polyclonal Antibody

    Western blot - ITPR1 Polyclonal Antibody

    Western blot analysis of extracts of various cell lines, using ITPR1 antibody at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit .Exposure time: 10s.

    Immunofluorescence - ITPR1 Polyclonal Antibody

    Immunofluorescence - ITPR1 Polyclonal Antibody

    Immunofluorescence analysis of U2OS cells using ITPR1 antibody at dilution of 1:100. Blue: DAPI for nuclear staining.

  • Background
    Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Involved in the regulation of epithelial secretion of electrolytes and fluid through the interaction with AHCYL1 (By similarity). Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity).

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"