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Recombinant ITPA protein (His tag)

Recombinant ITPA protein (His tag)

Cat.#: 543540

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Special Price 294.7 USD

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Product Information

  • Product Name
    Recombinant ITPA protein (His tag)
  • Documents
  • Description

    Recombinant Human Inosine triphosphate pyrophosphatase (ITPase) fragment (residues 2-194) is a high-purity, soluble protein designed for structural and biochemical studies. This stable fragment retains key functional domains, enabling research into non-canonical purine nucleotide hydrolysis and its role in maintaining genomic integrity.

    Inosine triphosphate pyrophosphatase (ITPase), encoded by the ITPA gene in Homo sapiens, is a cytoplasmic enzyme that hydrolyzes non-canonical purine nucleotides, including inosine triphosphate (ITP), deoxyinosine triphosphate (dITP), and xanthosine triphosphate (XTP), converting them to monophosphate derivatives. By excluding these aberrant nucleotides from RNA and DNA precursor pools, ITPase prevents their incorporation into nucleic acids, thereby safeguarding against chromosomal lesions and supporting genomic stability. This function underscores its importance in cellular nucleotide quality control and potential implications in disease mechanisms.

  • Protein name
    Inosine triphosphate pyrophosphatase
  • Uniprot ID
    Q9BY32
  • Gene Name
    ITPA; C20orf37
  • Source/Expression Host
    E. coli
  • Expression Plasmid/cDNA
    DNA encoding 2-194 aa (Q9BY32) were fused with 6His tag.
  • Protein Species
    Human
  • Molecular weight
    Predictes a molecular mass of 22.97 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 23 kDa band.
  • Purity
    >90%, by SDS-PAGE with Coomassie Brilliant Blue staining.
  • Activity
    Not tested.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"