Recombinant IRS1 protein (His tag)

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This product is a high-quality recombinant protein fragment of Insulin receptor substrate 1 (dIRS), also known as Protein chico, from Drosophila melanogaster. The fragment spans residues 1-232 and includes the complete PH domain, making it an excellent tool for studying domain-specific functions in insulin signaling pathways.

Insulin receptor substrate 1 (dIRS) in Drosophila melanogaster plays a critical role in the insulin/insulin-like growth factor (IGF) signaling pathway. It activates phosphatidylinositol 3-kinase by binding to its regulatory p85 subunit and mediates cellular responses to insulin-like peptides, including control of cell proliferation, cell size, organ growth, and developmental processes. Additionally, it is involved in signaling pathways that enable organisms to endure low-nutrient conditions and has roles in regulating aging and vitellogenic maturation in the ovary. Phosphorylation by the insulin receptor allows dIRS to interact with various SH2 domain-containing proteins, facilitating diverse cellular processes.