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  • IRF8 antibody
  • IRF8 antibody
  • IRF8 antibody

IRF8 antibody

Cat.#: 111841

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Special Price 239.0 USD

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Product Information

  • Product Name
    IRF8 antibody
  • Documents
  • Description
    IRF8 Rabbit Polyclonal antibody. Positive IHC detected in human lymphoma. Positive WB detected in mouse spleen tissue. Observed molecular weight by Western-blot: 48kd
  • Tested applications
    ELISA, WB, IHC
  • Species reactivity
    human, mouse; other species not tested.
  • Alternative names
    IRF8 antibody; ICSBP antibody; H ICSBP antibody; interferon regulatory factor 8 antibody; IRF 8 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of Peptide (Accession Number: NM_002163). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IHC: 1:20-1:200

  • Validations

    mouse spleen tissue were subjected to SDS PAGE followed by western blot with Catalog No:111841(IRF8 antibody) at dilution of 1:300

    mouse spleen tissue were subjected to SDS PAGE followed by western blot with Catalog No:111841(IRF8 antibody) at dilution of 1:300

    Immunohistochemical of paraffin-embedded human lymphoma using Catalog No:111841(IRF8 antibody) at dilution of 1:100 (under 10x lens)

    Immunohistochemical of paraffin-embedded human lymphoma using Catalog No:111841(IRF8 antibody) at dilution of 1:100 (under 10x lens)

    Immunohistochemical of paraffin-embedded human lymphoma using Catalog No:111841(IRF8 antibody) at dilution of 1:100 (under 40x lens)

    Immunohistochemical of paraffin-embedded human lymphoma using Catalog No:111841(IRF8 antibody) at dilution of 1:100 (under 40x lens)

  • Background
    IRF8 also named as ICSBP1, is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection. IRF8 specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). It plays a negative regulatory role in cells of the immune system. It is predominantly in lymphoid tissues.
  • References

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"