IRF8 Rabbit Polyclonal antibody. Positive IHC detected in human lymphoma. Positive WB detected in mouse spleen tissue. Observed molecular weight by Western-blot: 48kd
ELISA, WB, IHC
human, mouse; other species not tested.
IRF8 antibody; ICSBP antibody; H ICSBP antibody; interferon regulatory factor 8 antibody; IRF 8 antibody
This antibody was obtained by immunization of Peptide (Accession Number: NM_002163). Purification method: Antigen affinity purified.
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Store at -20℃. DO NOT ALIQUOT
mouse spleen tissue were subjected to SDS PAGE followed by western blot with Catalog No:111841(IRF8 antibody) at dilution of 1:300
Immunohistochemical of paraffin-embedded human lymphoma using Catalog No:111841(IRF8 antibody) at dilution of 1:100 (under 10x lens)
Immunohistochemical of paraffin-embedded human lymphoma using Catalog No:111841(IRF8 antibody) at dilution of 1:100 (under 40x lens)
IRF8 also named as ICSBP1, is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection. IRF8 specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). It plays a negative regulatory role in cells of the immune system. It is predominantly in lymphoid tissues.
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