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Product Name
Recombinant IREB2 protein (His tag)
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Description
Introducing the recombinant human Iron-responsive element-binding protein 2 (IRE-BP 2) fragment (amino acids 1-134), a highly stable and soluble protein unit ideal for investigating iron metabolism regulation and RNA-binding mechanisms in structural and biochemical studies.
Iron-responsive element-binding protein 2 (IRE-BP 2), also known as Iron regulatory protein 2 (IRP2), is a key RNA-binding protein in humans that regulates cellular iron homeostasis by binding to iron-responsive elements (IREs) in specific mRNAs. It represses the translation of ferritin mRNA and stabilizes transferrin receptor mRNA, thereby controlling iron storage and uptake. This protein is localized in the cytoplasm, where it plays a critical role in maintaining iron balance, as evidenced by its functional characterization (PubMed:7983023). The provided fragment represents a computationally optimized region designed for enhanced experimental utility.
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Protein name
Iron-responsive element-binding protein 2
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Uniprot ID
P48200
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Gene Name
IREB2
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 1-134 aa (P48200) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 16.74 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 18 kDa band.
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Purity
>89%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"