Interleukin-4 Receptor Targeting Peptide AP

Interleukin-4 Receptor Targeting Peptide AP

• COA/MS/HPLC Report
• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-CRKRLDRNC-OH

H-Cys-Arg-Lys-Arg-Leu-Asp-Arg-Asn-Cys-OH

9

97.95%

C₄₄H₈₂N₂₀O₁₃S₂

1163.37

Synthetic

Powder

Atherosclerotic plaque (AP) homing nonapeptide (CRKRLDRNC) was identified after cycles of ex vivophage display screening on human atheroma tissue and further validated for its targeting capability to the atherosclerotic plaques in an in vivomurine model. A homology sequence search identified the AP binding sequence KRLDRN motif corresponding to Interleukin-4 (IL-4). Its receptor, IL-4R, is abundantly expressed by glioma cells, thereby presenting the CRKRLDRNC as a potential tool for glioma targeting. Park et al. reported promising results with the AP peptide conjugated to doxorubicin-containing microbubbles and nanoliposomes as a proof-of-concept for targeted imaging and intervention in glioma using the U87MG in vitromodels. AP peptide conjugated to doxorubicin-containing liposomes also demonstrated enhanced antitumor efficacy in an in vivomodel of human lung cancer.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Hong HY, Lee HY, Kwak W, Yoo J, Na MH, So IS, et al. Phage display selection of peptides that home to atherosclerotic plaques: IL-4 receptor as a candidate target in atherosclerosis. J Cell Mol Med. 2008;12(5B):2003-14

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.