Recombinant INP5E protein (His tag)

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Recombinant Inositol polyphosphate 5-phosphatase E (INPP5E) fragment (residues 357-747) from Drosophila melanogaster, a highly stable and soluble protein unit optimized for structural and biochemical studies. This fragment enables detailed investigation of phosphoinositide phosphatase activity, supporting research in ciliary signaling and membrane dynamics.

Inositol polyphosphate 5-phosphatase E (INPP5E) is a key enzyme that converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns-P2 and phosphatidylinositol 4,5-bisphosphate (PtdIns 4,5-P2) to phosphatidylinositol 4-phosphate (PI-4-P). By regulating the phosphoinositide composition of the cilia membrane in auditory receptor neurons, it controls the localization of ktub and transient receptor potential channels such as iav and nompC, playing a critical role in ciliary function and sensory signaling. The protein is specifically localized to the transition zone of cell projections and cilia, marking the boundary between the plasma membrane and ciliary membrane, underscoring its importance in cellular compartmentalization and signal transduction pathways.