Recombinant INHBB protein (His tag)

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Recombinant Human Inhibin beta B chain (Activin beta-B chain) Fragment (residues 293-407) is a 115-amino acid protein segment derived from the INHBB gene. This fragment is designed for structural and biochemical studies, offering a stable and soluble unit ideal for investigating activin and inhibin signaling pathways in reproductive biology, metabolism, and cell differentiation.

The full-length Inhibin beta B chain is a component of both activin B and inhibin B, which are critical regulators of pituitary hormone secretion, embryonic development, stem cell maintenance, and metabolic processes. Activin B signals through receptors such as ACVR1C and ACVR2A, activating SMAD2/SMAD3 pathways to influence hepcidin induction, adipocyte lipid metabolism, and wound healing. Inhibin B functions as a potent antagonist of activin signaling, competitively binding activin type II receptors to suppress follicle-stimulating hormone (FSH) release and maintain reproductive homeostasis. As a secreted protein, it operates extracellularly, modulating diverse physiological functions from hematopoiesis to neural survival.

293-407