Recombinant IMP3 protein (His tag)

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Recombinant Human IMP3 (U3 snoRNP protein IMP3) Fragment (aa 1-184) - A high-purity protein fragment encompassing the complete S4 RNA-binding domain, ideal for studying ribosomal RNA processing mechanisms and nucleolar function in eukaryotic cells.

IMP3 is a crucial component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP) complex, essential for the early cleavage events during pre-18S ribosomal RNA processing. As part of the small subunit (SSU) processome, the first precursor of the small eukaryotic ribosomal subunit, IMP3 contributes to ribosome biogenesis by associating with nascent pre-rRNA to facilitate proper RNA folding, modifications, rearrangements, and cleavage. The protein is exclusively localized to the nucleus and nucleolus, where it participates in coordinated RNA processing events, including targeted degradation of pre-ribosomal RNA by the RNA exosome. This recombinant fragment containing the full S4 RNA-binding domain enables focused investigation of IMP3's specific molecular interactions in ribosomal biogenesis pathways.