Recombinant IL3 protein (His tag)

• DataSheet
• Material Safety Data Sheets (MSDS)

This recombinant protein product features a stable and soluble fragment (residues 20-152) of human Interleukin-3 (IL-3), a key hematopoietic growth factor. Engineered for structural and biochemical studies, this fragment retains critical functional regions, making it ideal for investigating IL-3's role in immune cell differentiation and activation.

Interleukin-3 (IL-3) is a cytokine primarily secreted by activated T-lymphocytes, mast cells, and osteoblastic cells. It plays a central role in hematopoiesis by regulating the production and differentiation of hematopoietic progenitor cells into lineage-specific cells, such as basophils, eosinophils, and monocytes, which it also activates. Beyond the immune system, IL-3 contributes to neural cell proliferation and survival, bone homeostasis by inhibiting osteoclast differentiation, and cell survival under oxidative stress via PI3K/AKT and ERK pathways. Its biological effects are mediated through a receptor complex involving IL3RA and IL3RB subunits, leading to JAK2/STAT5 signaling. As a secreted protein, IL-3 functions extracellularly, influencing diverse physiological processes from immunity to neural and bone metabolism.