Recombinant IL26 protein (His tag)

• DataSheet
• Material Safety Data Sheets (MSDS)

Recombinant Human Interleukin-26 (IL-26) Fragment (31-171) is a high-purity, soluble protein designed for robust structural and functional studies. This fragment, derived from the full-length IL-26 (Protein AK155), retains key biological activity and is ideal for investigating its role in mucosal immunity and inflammatory processes.

Interleukin-26 (IL-26), encoded by the IL26 gene, is a secreted cytokine involved in local mucosal immunity and exhibits pro-inflammatory functions. It plays a significant role in inflammatory bowel disease by activating signaling pathways such as STAT1, STAT3, MAPK1/3 (ERK1/2), JUN, and AKT. IL-26 induces expression of SOCS3, TNF-alpha, and IL-8, promotes secretion of IL-8 and IL-10, and enhances surface expression of ICAM1, while also reducing intestinal epithelial cell proliferation. Its activity is inhibited by heparin, highlighting its regulatory mechanisms in immune and inflammatory responses.