Recombinant IL1R2 protein (His tag)

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Recombinant Human Interleukin-1 Receptor Type 2 (IL-1R2) Fragment (aa 14-343) - A high-purity protein fragment encompassing the complete Ig-like C2-type domains 1 and 2, designed for studying IL-1B binding and decoy receptor mechanisms in inflammatory signaling pathways.

Interleukin-1 receptor type 2 (IL-1R2) functions as a critical non-signaling decoy receptor that competitively binds IL1A, IL1B, and IL1RN, primarily reducing IL1B activities by preventing its interaction with the signaling receptor IL1R1. The full-length protein exists in both membrane-bound and soluble forms, with the membrane form being a single-pass type I membrane protein and the soluble form secreted extracellularly. IL1R2 modulates cellular responses through non-signaling association with IL1RAP after IL1B binding, and the secreted form complexed with IL1RAP serves as a dominant mechanism for IL1B neutralization. This receptor plays a key regulatory role in inflammatory processes by acting as a molecular sink for IL-1 ligands.