Recombinant IL18 protein (His tag)

• DataSheet
• Material Safety Data Sheets (MSDS)

Recombinant Human Interleukin-18 (IL-18) Fragment (aa 37-193) is a high-purity, soluble protein designed for robust structural and functional studies. This fragment encompasses the biologically active core of IL-18, supporting research into inflammation, immune cell activation, and epithelial repair mechanisms.

Interleukin-18 (IL-18) is a pro-inflammatory cytokine critical for epithelial barrier repair and polarized T-helper 1 (Th1) and natural killer (NK) cell immune responses. It functions by binding to IL18R1 and IL18RAP, forming a signaling complex that activates NF-kappa-B and triggers synthesis of inflammatory mediators. IL-18 synergizes with IL-12 to induce interferon-gamma (IFNG) production and is released during pyroptosis via gasdermin-D (GSDMD) pores. The full-length protein is initially cytosolic and, upon inflammasome activation, is cleaved by caspases (CASP1/4/5) into its mature secreted form, which is released through TMED10-dependent unfolding. The recombinant fragment (aa 37-193) represents a stable, soluble unit ideal for investigating IL-18's role in inflammation and immunity.