Recombinant IL13 protein (His tag)

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Recombinant Human Interleukin-13 (IL-13) Fragment (aa 25-146) is a highly stable and soluble protein unit designed for structural and biochemical research. This fragment retains key functional characteristics of IL-13, enabling studies on allergic inflammation, immune regulation, and cytokine signaling pathways.

Interleukin-13 (IL-13) is a crucial cytokine involved in allergic inflammation and immune responses to parasitic infections. It functions by stimulating B-cell proliferation and activating eosinophils, basophils, and mast cells, while also modulating inflammatory responses through suppression of NF-kappa-B and proinflammatory cytokines like IL1, IL6, and TNF-alpha. IL-13 exerts its effects via receptors IL4R and IL13RA1, activating JAK1/TYK2 and STAT6 signaling pathways, with IL13RA2 serving as a decoy receptor. As a secreted protein, IL-13 plays roles in both hematopoietic and non-hematopoietic cells, including endothelial cells where it induces vascular adhesion molecules important for immune cell recruitment.