Recombinant IGHG4 protein (His tag)

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Recombinant Human Immunoglobulin Heavy Constant Gamma 4 (Ig gamma-4 chain C region) fragment (aa 1-347) is a high-purity protein encompassing the complete Ig-like 1, 2, and 3 domains. This fragment serves as an essential tool for investigating the structural and functional properties of the IgG4 constant region, supporting research in antibody engineering, immunology, and therapeutic development.

Immunoglobulin heavy constant gamma 4 is the constant region of immunoglobulin heavy chains, which are glycoproteins produced by B lymphocytes. In humoral immunity, membrane-bound immunoglobulins act as antigen receptors on B cells, triggering clonal expansion and differentiation into antibody-secreting plasma cells upon antigen binding. Secreted immunoglobulins execute the effector phase, leading to antigen elimination. Each immunoglobulin contains two antigen-binding sites formed by variable domains from one heavy chain and its associated light chain, with affinity maturation achieved through V-(D)-J rearrangement and somatic hypermutation. The full-length protein includes isoforms that are either secreted or single-pass membrane proteins, highlighting its dual roles in immune recognition and response.