Recombinant IFNL3 protein (His tag)

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Recombinant Human Interferon lambda-3 (IFN-lambda-3) Fragment (aa 36-196) is a high-purity, soluble protein designed for structural and functional studies. This 161-amino acid fragment retains key biological activity, offering researchers a reliable tool to investigate its antiviral, antitumour, and immunomodulatory properties in epithelial cell systems.

Interferon lambda-3 (IFN-lambda-3), also known as IL-28B, is a cytokine critical for antiviral host defense, particularly in epithelial tissues. It functions by binding to the heterodimeric receptor complex (IL10RB/IFNLR1), activating the JAK/STAT signaling pathway to induce interferon-stimulated genes (ISGs) that establish an antiviral state. Its immunomodulatory role includes upregulation of MHC class I antigen expression. The protein is naturally secreted and plays a specialized role in Toll-like receptor (TLR)-mediated antiviral responses, especially within the intestinal epithelium. This recombinant fragment corresponds to a stable, soluble region optimized for biochemical and structural applications.