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Product Name
Recombinant IFNL2 protein (His tag)
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Description
Recombinant Human Interferon lambda-2 (IFN-lambda-2) Fragment (aa 41-200) is a high-purity, soluble protein designed for structural and functional studies. This 160-amino acid fragment retains key biological activity, offering researchers a stable tool to investigate its antiviral, antitumour, and immunomodulatory properties in epithelial cell systems.
Interferon lambda-2 (also known as IL-28A) is a human cytokine critical for antiviral host defense, particularly in epithelial tissues. It functions by binding to the heterodimeric receptor IL10RB/IFNLR1, activating the JAK/STAT signaling pathway to induce interferon-stimulated genes (ISGs) that establish an antiviral state. This secreted protein demonstrates immunomodulatory activity through up-regulation of MHC class I antigen expression and plays a significant role in TLR-induced antiviral defense in intestinal epithelium. The full-length protein's selective action in epithelial cells stems from the tissue-specific expression of its IFNLR1 receptor subunit.
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Protein name
Interferon lambda-2
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Uniprot ID
Q8IZJ0
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Gene Name
IFNL2; IL28A; ZCYTO20
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 41-200 aa (Q8IZJ0) were fused with 6His tag.
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Sequence
41-200
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 19.90 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 20 kDa band.
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Purity
>87%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"