Recombinant IFNL1 protein (His tag)

• DataSheet
• Material Safety Data Sheets (MSDS)

Recombinant Human Interferon lambda-1 (IFN-lambda-1), also known as IL-29, is a high-purity protein fragment (amino acids 34-200) designed for robust performance in antiviral, antitumour, and immunomodulatory research. This 167-amino acid fragment was computationally optimized for stability and solubility, making it ideal for structural studies, biochemical assays, and functional investigations.

Interferon lambda-1 is a cytokine that plays a critical role in the antiviral host defense, particularly within epithelial tissues. It functions by binding to the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, activating the JAK/STAT signaling pathway. This activation leads to the expression of interferon-stimulated genes (ISGs), which establish an antiviral state. The protein also exhibits immunomodulatory properties by up-regulating MHC class I antigen expression. Its activity is cell type-selective due to the restricted expression of its receptor IFNLR1, primarily in epithelial cells. The full-length protein is naturally secreted, as indicated by its subcellular location.

34-200