Cart 2

IFNGR2 antibody

Cat.#: 111629

Size:

Special Price 239.0 USD

Availability: In Stock
- +

Add to cart to get an online quotation

Product Information

  • Product Name
    IFNGR2 antibody
  • Documents
  • Description
    IFNGR2 Rabbit Polyclonal antibody. Positive FC detected in HeLa cells. Positive WB detected in A549 cells, HeLa cells, HepG2 cells. Observed molecular weight by Western-blot: 55 kDa
  • Tested applications
    ELISA, WB, FC
  • Species reactivity
    Human; other species not tested.
  • Alternative names
    AF 1 antibody; IFGR2 antibody; IFN gamma R2 antibody; IFN gamma receptor 2 antibody; IFNGR2 antibody; IFNGT1 antibody; Interferon gamma receptor 2 antibody; Interferon gamma transducer 1 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of IFNGR2 recombinant protein (Accession Number: NM_005534). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:200-1:2000

  • Validations

    A549 cells were subjected to SDS PAGE followed by western blot with Catalog No:111629(IFNGR2 antibody) at dilution of 1:500

    A549 cells were subjected to SDS PAGE followed by western blot with Catalog No:111629(IFNGR2 antibody) at dilution of 1:500

    1X10^6 HeLa cells were stained with 0.2ug IFNGR2 antibody (Catalog No:111629, red) and control antibody (blue). Fixed with 90% MeOH blocked with 3% BSA (30 min). Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L) with dilution 1:1500.

    1X10^6 HeLa cells were stained with 0.2ug IFNGR2 antibody (Catalog No:111629, red) and control antibody (blue). Fixed with 90% MeOH blocked with 3% BSA (30 min). Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L) with dilution 1:1500.

  • Background
    Interferon-gamam (IFN-γ) is a cytokine critical for innate and adaptive immunity against viral and intracellular bacterial infections and for tumor control. Cellular responses to IFN-γ are activated through its interaction with a heterodimeric receptor consisting of two subunits, IFNGR1 and IFNGR2. IFNGR1 is the ligand-binding subunit which binds IFN-γ with high affinity, whereas IFNGR2 serves as the accessory subunit which attaches to IFN-γ with a significantly lower affinity. Two subunits bind one IFN-γ dimer. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. (PMID: 17981204; 946248; 10888113)

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"