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Product Name
Recombinant IFIT2 protein (His tag)
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Description
Recombinant Human IFIT-2 (Interferon-induced protein with tetratricopeptide repeats 2) fragment (residues 2-472) is a high-purity, stable protein designed for structural and functional studies. This 471-amino acid fragment retains key domains essential for investigating IFIT-2's role in antiviral defense and RNA binding mechanisms.
IFIT-2 is an interferon-induced antiviral protein that inhibits viral replication by targeting mRNAs lacking 2'-O-methylation of their 5' cap, a key mechanism for distinguishing host from viral RNA. It binds AU-rich viral RNAs, regardless of 5' triphosphorylation, and this RNA-binding capability is critical for its antiviral activity. Additionally, IFIT-2 can promote apoptosis and is localized in the cytoplasm and endoplasmic reticulum, underscoring its involvement in cellular defense pathways. This recombinant fragment provides a soluble, functional unit ideal for exploring these biological roles in detail.
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Protein name
Interferon-induced protein with tetratricopeptide repeats 2
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Uniprot ID
P09913
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Gene Name
IFIT2; CIG-42; G10P2; IFI54; ISG54
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 2-472 aa (P09913) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 56.16 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 62 kDa band.
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Purity
>87%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"