-
Product Name
Recombinant IDHP protein (His tag)
- Documents
-
Description
Introducing the recombinant human Isocitrate dehydrogenase [NADP], mitochondrial (IDH) fragment (residues 41-452), a high-quality protein designed for structural and biochemical studies. This 412-amino acid fragment, derived from the IDH2 gene, represents a stable and soluble unit optimized for research into intermediary metabolism and energy production pathways.
Isocitrate dehydrogenase [NADP], mitochondrial (IDH) is a crucial enzyme encoded by the IDH2 gene that plays a fundamental role in cellular intermediary metabolism and energy production. Located within the mitochondria, this enzyme catalyzes the oxidative decarboxylation of isocitrate to α-ketoglutarate while generating NADPH. Research indicates that IDH may associate or interact with the pyruvate dehydrogenase complex, suggesting its integration into broader metabolic networks. The mitochondrial localization underscores its importance in cellular energy metabolism, making it a significant target for metabolic and biochemical research.
-
Protein name
Isocitrate dehydrogenase [NADP], mitochondrial
-
Uniprot ID
P48735
-
Gene Name
IDH2
-
Source/Expression Host
E. coli
-
Expression Plasmid/cDNA
DNA encoding 41-452 aa (P48735) were fused with 6His tag.
-
Protein Species
Human
-
Molecular weight
Predictes a molecular mass of 48.20 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 49 kDa band.
-
Purity
>85%, by SDS-PAGE with Coomassie Brilliant Blue staining.
-
Activity
Not tested.
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"