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Product Name
Recombinant I2BP2 protein (His tag)
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Description
Recombinant IRF-2BP2 Fragment (502-587) is a high-quality, stable protein fragment derived from human Interferon regulatory factor 2-binding protein 2. This 86-amino acid fragment is engineered for solubility and structural integrity, making it ideal for biochemical assays, structural studies, and functional investigations into transcriptional regulation.
Interferon regulatory factor 2-binding protein 2 (IRF-2BP2) is a versatile transcriptional coregulator in humans, localized in both the nucleus and cytoplasm. It functions as a corepressor in an IRF2-dependent manner without involving histone deacetylase activities, represses NFAT1-mediated transactivation of NFAT-responsive promoters, and acts as a coactivator for VEGFA expression in cardiac and skeletal muscles. Additionally, IRF-2BP2 plays a critical role in immature B-cell differentiation, highlighting its importance in immune and developmental processes. The provided fragment (residues 502-587) was selected computationally for its stability and solubility, enabling focused studies on its functional domains.
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Protein name
Interferon regulatory factor 2-binding protein 2
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Uniprot ID
Q7Z5L9
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Gene Name
IRF2BP2
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 502-587 aa (Q7Z5L9) were fused with 6His tag.
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Sequence
502-587
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 11.07 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 11 kDa band.
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Purity
>90%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"