HUWE1 antibody

HUWE1 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

HUWE1 Rabbit Polyclonal antibody. Positive WB detected in HEK-293. Observed molecular weight by Western-blot: 482 kDa

ELISA, WB

Human,Mouse,Rat; other species not tested.

ARF binding protein 1 antibody; ARF BP1 antibody; HECTH9 antibody; HSPC272 antibody; HUWE1 antibody; Ib772 antibody; KIAA0312 antibody; KIAA1578 antibody; Large structure of UREB1 antibody; LASU1 antibody; Mcl 1 ubiquitin ligase E3 antibody; MULE antibody; URE B1 antibody; URE binding protein 1 antibody; UREB1 antibody

Rabbit IgG

This antibody was obtained by immunization of HUWE1 recombinant protein (Accession Number: BC002602). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Huwe1 encodes a HECT domain ubiquitin ligase. HUWE1 is a large protein (500 kDa) that has attracted considerable interest because several and quite disparate substrates have been assigned to this E3. HUWE1 is essential for proliferation of a subset of tumor cells, and negative regulator of TP53 during the colorectal carcinoma progression through the ubiquitination pathway mediated by the HECT domain. It has a role in regulating Berg-mann glia differentiation and this ubiquitin ligase orchestrates the programming of the neural progenitors that give rise to neurons and glia in the cerebellum.