Human URM1 Recombinant protein (GST tag)

Human URM1 Recombinant protein (GST tag)

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Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as MOCS3, ATPBD3, CTU2, USP15 and CAS. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates. {HAMAP-Rule:MF_03048, PubMed:19017811, PubMed:21209336}.

Ubiquitin-related modifier 1

C9orf74

Q9BTM9

URM1; C9orf74

E. coli

A DNA sequence encoding the human URM1 (NP_112176.1) 1-101 aa was fused with the N-terminal GST tag

Human

Not tested.