Human TRIB2 / TRB2 (His & GST Tag) recombinant protein

Cat.#: 503617

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Product Information

  • Product Name
    Human TRIB2 / TRB2 (His & GST Tag) recombinant protein
  • Documents
  • Description
    Tribbles homolog 2, also known as TRB-2, and Trib2, is a member of the protein kinase superfamily and Tribbles subfamily (Trib1, Trib2, Trib3). The identification of tribbles as regulators of signal processing systems and physiological processes, including development, together with their potential involvement in diabetes and cancer, has generated considerable interest in these proteins. Tribbles have been reported to regulate activation of a number of intracellular signalling pathways with roles extending from mitosis and cell activation to apoptosis and modulation of gene expression. Tribbles controls the timing of mitosis in the prospective mesoderm, allowing cell-shape changes to be completed. This mechanism for coordinating cell division and cell-shape changes may have helped Drosophila to evolve its mode of rapid early development. Trib2 was identified as a downregulated transcript in leukemic cells undergoing growth arrest. Trib2-transduced bone marrow cells exhibited a growth advantage and readily established factor-dependent cell lines. Trib2-reconstituted mice uniformly developed fatal transplantable acute myelogenous leukemia (AML).
  • Protein name
    HCG18830, isoform CRA_a
  • Protein short names
    C5FW; GS3955; AW319517; TRB2; TRIB2; TRB-2; FLJ57420
  • Uniprot ID
    Q16816
  • Gene Name
    hCG_18830
  • Source/Expression Host
    Baculovirus-Insect Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the human TRIB2 (NP_006204.1) (Met 1-Asn 343) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
  • Protein Species
    Human
  • Molecular weight
    The recombinant human TRIB2/GST chimera consists of 580 amino acids and predicts a molecular mass of 66.6 kDa. It migrates as an approximately 60 kDa band in SDS-PAGE under reducing conditions.
  • Purity
    > 82 % as determined by SDS-PAGE
  • Activity
    Kinase activity untested
  • Validations

    Human TRIB2 / TRB2 Protein (His & GST Tag) SDS-PAGE

    Human TRIB2 / TRB2 Protein (His & GST Tag) SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"