Human TP53INP1 Recombinant protein (His tag)

Human TP53INP1 Recombinant protein (His tag)

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Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC. {PubMed:11511362, PubMed:22421968, PubMed:22470510}.

Tumor protein p53-inducible nuclear protein 1

P53DINP1; SIP

Q96A56

TP53INP1; P53DINP1; SIP

E. coli

A DNA sequence encoding the human TP53INP1 (XP_011515688.1) 1-240 aa was fused with the polyhistidine tag

Human

Not tested.