Human TNFRSF17/BCMA?CD269? (His & Fc Tag) recombinant protein

Human TNFRSF17/BCMA?CD269? (His & Fc Tag) recombinant protein

• DataSheet
• Material Safety Data Sheets (MSDS)

Tumor necrosis factor receptor superfamily, member 17 (TNFRSF17), also known as B cell maturation antigen (BCMA) or CD269 antigen, is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13BBAFF), and to lead to NF-kappaB and MAPK8/JNK activation. TNFRSF17/BCMA/CD269 also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. TNFRSF17/BCMA/CD269 is a receptor for TALL-1 and BCMA activates NF-kappaB through a TRAF5-, TRAF6-, NIK-, and IKK-dependent pathway. The identification of TNFRSF17 as a NF-kappaB-activating receptor for TALL-1 suggests molecular targets for drug development against certain immunodeficient or autoimmune diseases. TNFRSF17/BCMA is a target of donor B-cell immunity in patients with myeloma who respond to DLI. Antibody responses to cell-surface BCMA may contribute directly to tumor rejection in vivo.

Tumor necrosis factor receptor superfamily member 17

BCMA; CD269; TNFRSF13A; TNFRSF17; TNFRSF13; BCM

Q02223

TNFRSF17; BCM; BCMA

Human Cells

A DNA sequence encoding the extracellular domain of human TNFRSF17 (NP_001183.2) (Met 1-Ala 54) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus and a signal peptide at the N-terminus.

Human

The recombinant human TNFRSF17/Fc is a disulfide-linked homodimer. The reduced monomer comprises 302 amino acids after removal of the signal peptide and has a predicted molecular mass of 34 kDa. As a result of glycosylation, the apparent molecular mass of rh TNFRSF17/Fc monomer is approximately 40 kDa in SDS-PAGE under reducing conditions.

> 85 % as determined by SDS-PAGE

Measured by its binding ability in a functional ELISA. Immobilized recombinant human BAFF at 1 μg/ml (100 μl/well) can bind human TNFRSF17. The EC₅₀ of human TNFRSF17 is 0.07 μg/ml.