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Product Name
Human TIMP-2/TIMP2 (Fc Tag) recombinant protein
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Description
Tissue inhibitors of metalloproteinases (TIMP) family are natural inhibitors of the matrix metalloproteinases (MMPs), the zinc enzymes involved in extracellular matrix maintenance and remodeling. The TIMP family encompasses four members (TIMP1-4), and they inhibit most MMPs by forming non-covalent binary complex. TIMP2 is a 22 kDa non N-glycosylated protein expressed by a variety of cell types, and plays a unique role among TIMP family members owing to its functions to regulate cellular responses to growth factors. Findings establish an unexpected, MMP-independent mechanism for TIMP2 inhibition of endothelial cell proliferation in vitro and reveal an important component of the antiangiogenic effect of TIMP2 in vivo. TIMP-2 thus is critical to the maintenance of tissue homeostasis and is involved in the regulation of tumor microenvironment.
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Protein name
Metalloproteinase inhibitor 2
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Protein short names
TIMP-2; TIMP2; D11BWG1104E; CSC-21K; RP23-394O9.2; DDC8
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Uniprot ID
P16035
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Gene Name
TIMP2
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the mature form of human TIMP2 (NP_003246.1) (Cys 27-Pro 220) was expressed with the fused Fc region of human IgG1 at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human Fc/TIMP2 is a disulfide-linked homodimeric protein. The reduced monomer consists of 431 amino acids and has a predicted molecular mass of 48 kDa as estimated in SDS-PAGE under reducing conditions.
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Purity
> 95 % as determined by SDS-PAGE
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Validations
Human TIMP2 / TIMP-2 Protein (Fc Tag) SDS-PAGE
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