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Product Name
Human Thrombopoietin/THPO (Fc Tag) recombinant protein
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Description
Thrombopoietin (TPO or THPO), also known as myeloproliferative leukemia virus ligand (c-Mpl), is a hematopoietic growth factor belonging to the EPO/TPO family. The thrombopoietin protein is produced mainly by the liver and the kidney that regulates the production of platelets by the bone marrow. Thrombopoietin protein stimulates both proliferation of progenitor megakaryocytes and their maturation to platelet-producing megakaryocytes, and also accelerates the recovery of platelets. Thrombopoietin protein is involved in cardiovascular disease as it regulates megakaryocyte development and enhances platelet adhesion/aggregation. It has been identified that surface c-MPL, the receptor for thrombopoietin protein, binds to the ligand and mediates the action.
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Protein name
Thrombopoietin
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Protein short names
TPO; MKCSF; TPO-4; RP23-148P12.1; THCYT1; THROMBOPOIETIN; MGC163194; TPO-1; THPO; TPO-3; MGDF; ML; TPO-2; MPLLG
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Uniprot ID
P40225
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Gene Name
THPO; MGDF
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Source/Expression Host
Human Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human THPO (NP_000451.1) (Met1-Leu192) was expressed with the Fc region of human IgG1 at the C-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human THPO consists 409 amino acids and predicts a molecular mass of 45 kDa.
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Purity
> 70 % as determined by SDS-PAGE.
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Validations
Human Thrombopoietin / THPO Protein (Fc Tag)
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