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Product Name
Human TFB2M Recombinant protein (His tag)
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Description
S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. Compared to TFB1M, it activates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity. {PubMed:12068295, PubMed:12897151, PubMed:15526033, PubMed:20410300}.
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Protein name
Dimethyladenosine transferase 2, mitochondrial
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Protein short names
NS5ATP5
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Uniprot ID
Q9H5Q4
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Gene Name
TFB2M; NS5ATP5
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human TFB2M (NP_071761.1) 176-396 aa was fused with the polyhistidine tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human TFB2M SDS-PAGE
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