Human SPHK1 / Sphingosine Kinase 1 recombinant protein
SPHK1, also known as sphingosine Kinase 1, catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P). S1P exhibits a broad spectrum of biological activities including cell proliferation, survival, migration, cytoskeletal organization, and morphogenesis. It is a ligand for cell surface G protein-coupled receptors. SPHK 1 is a potential therapeutic target for the control of cancer and inflammation. SPHK1 plays a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes.
Protein short names
SK 1; RP23-193A16.4; SPK1; 1110006G24RIK; SPHINGOSINE KINASE 1; SPHK1; SK1; SPHK; SPK 1
A DNA sequence encoding the human SPHK1 (Q9NYA1-1)(Met1-Leu384) was fused with two additional amino acids (Gly & Pro) at the N-terminus.
The recombinant human SPHK1 consists of 386 amino acids and has a calculated molecular mass of 42.7 kDa. The recombinant protein migrates as an approximately 46 kDa band in SDS-PAGE under reducing conditions.
> 85 % as determined by SDS-PAGE
The specific activity was determined to be 1028 nmol/min/mg using Sphingosine Kinase Substrate as substrate.
Human SPHK1 / Sphingosine Kinase 1 Protein SDS-PAGE
Related Products / Services
- Recombinant Proteins
- cDNA Clones
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