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Product Name
Human RPE65 Recombinant protein (His tag)
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Description
Plays important roles in the production of 11-cis retinal and in visual pigment regeneration. The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated by LRAT, binds all-trans-retinyl esters, making them available for IMH (isomerohydrolase) processing to all-cis-retinol. The soluble form is regenerated by transferring its palmitoyl groups onto 11-cis-retinol, a reaction catalyzed by LRAT. The enzymatic activity is linearly dependent of the expression levels and membrane association. {PubMed:16116091, PubMed:21654732}.
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Protein name
Retinoid isomerohydrolase
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Uniprot ID
Q16518
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Gene Name
RPE65
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human RPE65 (NP_000320.1) 204-533 aa was fused with the polyhistidine tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human RPE65 SDS-PAGE
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