Human PNPT1 Recombinant protein (His tag)

Human PNPT1 Recombinant protein (His tag)

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RNA-binding protein implicated in numerous RNA metabolic processes. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'-to-5' direction. Mitochondrial intermembrane factor with RNA-processing exoribonulease activity. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Required for correct processing and polyadenylation of mitochondrial mRNAs. Plays a role as a cytoplasmic RNA import factor that mediates the translocation of small RNA components, like the 5S RNA, the RNA subunit of ribonuclease P and the mitochondrial RNA-processing (MRP) RNA, into the mitochondrial matrix. Plays a role in mitochondrial morphogenesis and respiration; regulates the expression of the electron transport chain (ETC) components at the mRNA and protein levels. In the cytoplasm, shows a 3'-to-5' exoribonuclease mediating mRNA degradation activity; degrades c-myc mRNA upon treatment with IFNB1/IFN-beta, resulting in a growth arrest in melanoma cells. Regulates the stability of specific mature miRNAs in melanoma cells; specifically and selectively degrades miR-221, preferentially. Plays also a role in RNA cell surveillance by cleaning up oxidized RNAs. Binds to the RNA subunit of ribonuclease P, MRP RNA and miR-221 microRNA. {PubMed:12473748, PubMed:12721301, PubMed:12798676, PubMed:16055741, PubMed:16410805, PubMed:16934922, PubMed:18083836, PubMed:18083837, PubMed:18501193, PubMed:19509288, PubMed:20547861, PubMed:20691904}.

Polyribonucleotide nucleotidyltransferase 1, mitochondrial

PNPASE

Q8TCS8

PNPT1; PNPASE

E. coli

A DNA sequence encoding the human PNPT1 (NP_149100.2) 427-783 aa was fused with the polyhistidine tag

Human

Not tested.