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Product Name
Human PCBD1/DCOH/PCBD (His tag) recombinant protein
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Description
Pterin-4-α-Carbinolamine Dehydratase (PCBD1) is the founding member of the Pterin-4-α-Carbinolamine Dehydratase Family. PCBD1 is involved in Tetrahydrobiopterin biosynthesis. It seems to prevent the formation of 7-Pterins and accelerate the formation of Quinonoid-BH2. Furthermore, PCBD1 regulates the homodimerization of the transcription factor Hepatocyte Nuclear Factor 1 (HNF1) and enhances its transcriptional activity. Defects in PCBD1 are the cause of BH4-Deficient Hyperphenylalaninemia Type D (HPABH4D). HPABH4D is characterized by the excretion of 7-substituted Pterins in the urine of affected patients.
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Protein name
pterin-4 alpha-carbinolamine dehydratase 1(PCBD1)
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Protein short names
DCOH; PCBD
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Uniprot ID
P61457
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Source/Expression Host
E.coli
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Expression Plasmid/cDNA
A DNA sequence encoding the Human PCBD1/DCOH/PCBD Ala2-Thr104 is expressed with a 6His tag at the N-terminus.
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Protein Species
Human
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Purity
>95% as determined by SDS-PAGE.
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Validations
Human PCBD1/DCOH/PCBD (His tag) recombinant protein
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