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Product Name
Human NCF2 / NCF-2 / P67phox (His & GST Tag) recombinant protein
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Description
NCF2, also known as NCF-2 and p67phox, is a subunit of the multi-protein NADPH oxidase complex. NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in NCF2 gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms.
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Protein name
Neutrophil cytosol factor 2
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Protein short names
P67PHOX; RP1-127C7.5; NCF-2; NEUTROPHIL CYTOSOLIC FACTOR 2 (65KD; NEUTROPHIL CYTOSOLIC FACTOR 2; AUTOSOMAL 2; NADPH OXIDASE ACTIVATOR 2; AUTOSOMAL 2); 67 KDA NEUTROPHIL OXIDASE FACTOR; NEUTROPHIL CYTOSOL FACTOR 2; CHRONIC GRANULOMATOUS DISEASE; NOXA2; NEUTROPHIL NADPH OXIDASE FACTOR 2; NADPH OXIDASE SUBUNIT (67 KD); CHRONIC GRANULOMATOUS DISEASE; NCF2; NADPH OXIDASE SUBUNIT (67KDA); P67-PHOX
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Uniprot ID
P19878
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Gene Name
NCF2; NOXA2; P67PHOX
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Source/Expression Host
Baculovirus-Insect Cells
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Expression Plasmid/cDNA
A DNA sequence encoding the human NCF2 (AAH01606.1) (Met1-Val526) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
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Protein Species
Human
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Molecular weight
The recombinant human NCF2 /GST chimera consists of 763 amino acids and has a calculated molecular mass of 87.6 kDa. The recombinant protein migrates as an approximately 80-90 kDa band in SDS-PAGE under reducing conditions.
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Purity
> 90 % as determined by SDS-PAGE
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Validations
Human NCF-2 / NCF2 / P67phox Protein (His & GST Tag) SDS-PAGE
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