human MUC7 20-Mer peptide

human MUC7 20-Mer peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

LAHQKPFIRKSYKCLHKRCR

Leu-Ala-His-Gln-Lys-Pro-Phe-Ile-Arg-Lys-Ser-Tyr-Lys-Cys-Leu-His-Lys-Arg-Cys-Arg

20

97.6%

Synthetic

Powder

Derived from the C-terminal region (residues 32-51, where 7 out 8 basic residues are located) of MUC7 domain 1. Activity was initially reported in a previous study (Smith CJ and Bobek LA 2001 J Dent Res 80:601). Active against bacteria A. actinomycetemcomitans, E. coli, P. aeruginosa, S. mutans (cariogenic bacteria), P. gingivalis, and S. gordonii (MIC 1-4.4 uM), fungi C. albicans, C. glabrata, C. krusei, and C. neoformans CN2, and S. cerevisiae (MIC 2.4-5.8 uM) (including resistant forms of C. albicans, C. glabrata, and C, neoformans) (MIC 2.4-12.3 uM). The secondary structure prediction showed that MUC7 20-mer adopts an amphiphilic helix. The peptide is still active after removing the first eight residues (MUC7 12-mer). In saliva (proteases and ionic strength), the D-form of MUC7-12mer is more active than the L-form, although they showed similar activity in phosphate buffer (PBS) (D=L). Updated 12/2014. human MUC7 20-Mer has Antibacterial, Antifungal activity. human MUC7 20-Mer was found in Homo sapiens.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Bobek LA, Situ H. MUC7 20-Mer: investigation of antimicrobial activity, secondary structure, and possible mechanism of antifungal action. Antimicrob Agents Chemother. 2003;47(2):643-52.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.