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  • Human MASP1/CRARF/CRARF1/PRSS5 (His tag) recombinant protein

Human MASP1/CRARF/CRARF1/PRSS5 (His tag) recombinant protein

Cat.#: 519407

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Product Information

  • Product Name
    Human MASP1/CRARF/CRARF1/PRSS5 (His tag) recombinant protein
  • Documents
  • Description
    Mannan-Binding Lectin Serine Protease 1 (MASP-1) belongs to the peptidase S1 family. MASP1 contains two CUB domains, one EGF-like domain, one peptidase S1 domain and two Sushi (CCP/SCR) domains. MASP1 is primarily expressed in liver. MASP1 involved in the lectin pathway of the complement, performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. MASP1 is synthesized as a zymogen and activated when it complexes with the pathogen recognition molecules of lectin pathway, the mannose-binding lectin and the ficolins. MASP1 is not directly involved in complement activation but may act as an amplifier of complement activation by cleaving complement C2 or by activating another complement serine protease, MASP2. MASP1 is also able to cleave fibrinogen and factor XIII and may may be involved in coagulation. MASP1 is inhibited by SERPING1 and A2M.
  • Protein name
    mannan binding lectin serine peptidase 1(MASP1)
  • Protein short names
    CRARF; CRARF1; PRSS5
  • Uniprot ID
    P48740
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the Human MASP1/CRARF/CRARF1/PRSS5 His20-Arg728 is expressed with a 6His tag at the C-terminus.
  • Protein Species
    Human
  • Purity
    >95% as determined by SDS-PAGE.
  • Validations

    Human MASP1/CRARF/CRARF1/PRSS5 (His tag) recombinant protein

    Human MASP1/CRARF/CRARF1/PRSS5 (His tag) recombinant protein

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"