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Product Name
Human LPCAT2 Recombinant protein (GST tag)
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Description
Possesses both acyltransferase and acetyltransferase activities. Activity is calcium-dependent. Involved in platelet-activating factor (PAF) biosynthesis by catalyzing the conversion of the PAF precursor, 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) into 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF). Also converts lyso-PAF to 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine (PC), a major component of cell membranes and a PAF precursor. Under resting conditions, acyltransferase activity is preferred. Upon acute inflammatory stimulus, acetyltransferase activity is enhanced and PAF synthesis increases. Also catalyzes the conversion of 1-acyl-sn-glycero-3-phosphocholine to 1,2-diacyl-sn-glycero-3-phosphocholine. {PubMed:20363836, PubMed:21498505}.
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Protein name
Lysophosphatidylcholine acyltransferase 2
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Protein short names
AGPAT11; AYTL1
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Uniprot ID
Q7L5N7
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Gene Name
LPCAT2; AGPAT11; AYTL1
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human LPCAT2 (NP_060309.2) 161-544 aa was fused with the N-terminal GST tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human LPCAT2 SDS-PAGE
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